The purpose of this article is to examine Israel's security-military strategies to counter Iran's goals and interests in Syria from the emergence of ISIS to the fall of the Assad regime. This research, using a qualitative descriptive-analytical method and using library resources such as reading texts and taking notes, reading images, using maps, reading documents from some books, etc., both domestic and foreign, related to the subject, seeks to answer the main question: What are the main axes of Israel's security-military strategies against Iran in Syria from the emergence of ISIS to the fall of the Assad regime? The findings and conclusions of the article are based on the hypothesis that the confrontation between the Zionist regime and Iran in Syria, especially during the rise of ISIS until the fall of the Assad regime in 2024 and even today, that is, in the post-Assad era, was designed and implemented in the form of doctrines and strategies such as Eisenkot, the destruction of the octopus, Netanyahu's 2030 security, and the strategy of death with thousands of wounds to contain and control Iran in West Asia, specifically in the country of "Syria" and to change the revolutionary nature of Iran at home, and was accompanied by actions such as attacking Iranian ships, attacking Iranian interests in Iraq and Syria, cyber operations, supporting hostile and separatist groups and currents, drone and micro-aircraft operations, bombing and sabotage operations in sensitive places and facilities, and kidnapping and interrogation operations.