Science and technology parks play an important role in knowledge-based economic network through human resources management (HRM) and in cooperation with various regional institutions. Therefore, developing and analyzing a model for human resource management at science and technology parks is essential due to the importance and the interactive nature of the matter. More importantly, a study of the current HRM models at science and technology parks showed that they operate mostly on the one of the levels and elements within the value network of science and technology parks. Accordingly, this study attempts to elaborate on the interactive model based on the holistic nature of the system dynamics approach and its focus on the interaction among the various components of a system. The proposed model was developed and tested following 15 sessions of group model building with the stakeholders, and different scenarios were identified and simulated. The simulation results showed that focusing simultaneously on motivation and human resource quality of staff, gradual withdrawal of support and also developing communications within park's tenants, especially those used for technology transfer, market development and intellectual and human resource exchange are highly effective on productivity of the model.